Author(s):
Maddalena Mognato and Lucia CelottiPages 1052-1062 (11)
Abstract:
MicroRNAs (miRNAs), a recently discovered class of small non-coding RNAs, constitute a promising approach to anti-cancer treatments when they are used in combination with other agents. MiRNAs are evolutionarily conserved non-coding RNAs that negatively regulate gene expression...
Friday, August 19, 2016
G4 Aptamers: Trends in Structural Design
Author(s):
Anna Varizhuk, Nikolay Ilyinsky, Igor Smirnov and Galina PozmogovaPages 1-9 (9)
Abstract:
Many potent DNA aptamers are known to contain a G-quadruplex (G4) core. Structures and applications of the majority of such aptamers have been reviewed previously. The present review focuses on the design and optimization of G4 aptamers. General...
Augmentation of Creatine in the Heart
Author(s):
Sevasti Zervou, Hannah J. Whittington, Angela J. Russell and Craig A. LygatePages 19-28 (10)
Abstract:
Creatine is a principle component of the creatine kinase (CK) phosphagen system common to all vertebrates. It is found in excitable cells, such as cardiomyocytes, where it plays an important role in the buffering and transport of chemical...
RAS/Effector Interactions from Structural and Biophysical Perspective
Author(s):
Ariel Erijman and Julia M. ShifmanPages 370-375 (6)
Abstract:
RAS is a molecular switch that regulates a large number of pathways through interactions with many effector proteins. Most RAS/effector complexes are short-lived, demonstrating fast association and fast dissociation rate and Kds ranging from 10-8–10-5 M, compatible with...
Ras Dimer Formation as a New Signaling Mechanism and Potential Cancer Therapeutic Target
Author(s):
Mo Chen, Alec Peters, Tao Huang and Xiaolin NanPages 391-403 (13)
Abstract:
The K-, N-, and HRas small GTPases are key regulators of cell physiology and are frequently mutated in human cancers. Despite intensive research, previous efforts to target hyperactive Ras based on known mechanisms of Ras signaling have been met with little success....
